AN IMAGING-DRIVEN, MECHANICAL DEFORMATION-COUPLED REACTION-DIFFUSION MODEL FOR DESCRIBING TUMOR DEVELOPMENT

Anna Claudia Mello de Resende, Rafael Alves Bonfim de Queiroz, Ernesto Augusto Bueno da Fonseca Lima, Gustavo Taiji Naozuka, Regina Célia Cerqueira de Almeida

Resumo


Compressive stresses play important roles on tumor cells proliferation and invasion. In this work we propose to inform a tumor growth model with the recovered deformation coming from in vivo imaging data. We investigated the use of an optical flow technique, the well known Lucas-Kanade method, to capture tumor deformation in a synthetic experimental breast cancer setting. We compare displacements and stresses obtained with this method with those derived from a previously developed reaction-diffusion model with mechanical deformation. We show that the considered optical flow technique may capture deformations appearing in breast cancers, being a useful alternative to integrate in vivo data to mathematical tumor models.


Palavras-chave


Mathematical Model; Tumor Growth; Deformation; MRI; Optical Flow

Texto completo:

PDF


DOI: http://dx.doi.org/10.21575/25254782rmetg2020vol5n21142

Apontamentos

  • Não há apontamentos.


Direitos autorais 2020 Anna Claudia Resende, Rafael Queiroz, Ernesto Lima, Gustavo Naozuka, Regina Almeida

Revista Mundi Engenharia, Tecnologia e Gestão ISSN 2525-4782

Qualis: B4 - Interdisciplinar, B5 - Geografia, B5 - Administração Pública e de Empresas, Ciências Contábeis e Turismo, B5 - Comunicação e Informação, B5 - Engenharias III